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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Met77Thr

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 77 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Methionine (M) to Threonine (T) at position 77 (M77T, p.Met77Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (M) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Aztec. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 77 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help KGHGKKVADALTNAVAHVDD M PNALSALSDLHAHKLRVDPV The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPV

Gorilla                       KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPV

                              KAHGKKVADALTTAVAHLDDLPGALSALSDLHAYKLRVDPV

Rhesus macaque                KGHGKKVADALTLAVGHVDDMPNALSALSDLHAHKLRVDPV

Chimpanzee                    KGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPV

Mouse                         KGHGKKVADALASAAGHLDDLPGALSALSDLHAHKLRVDPV

Rat                           KAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPV

Pig                           KAHGQKVADALTKAVGHLDDLPGALSALSDLHAHKLRVDPV

Bovine                        KGHGAKVAAALTKAVEHLDDLPGALSELSDLHAHKLRVDPV

Rabbit                        KAHGKKVSEALTKAVGHLDDLPGALSTLSDLHAHKLRVDPV

Sheep                         KGHGEKVAAALTKAVGHLDDLPGTLSDLSDLHAHKLRVDPV

Cat                           KAHGQKVADALTQAVAHMDDLPTAMSALSDLHAYKLRVDPV

Horse                         KAHGKKVGDALTLAVGHLDDLPGALSNLSDLHAHKLRVDPV

Chicken                       KGHGKKVVAALIEAANHIDDIAGTLSKLSDLHAHKLRVDPV

Xenopus tropicalis            LAHGKKVSDALNEACNHLDNIAGCLSKLSDLHAYDLRVDPG

Zebrafish                     KKHGKTIMGAVGEAISKIDDLVGGLAALSELHAFKLRVDPA

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Domain 2 – 142 Globin
Binding site 59 – 59
Binding site 88 – 88 proximal binding residue
Site 57 – 57 Not glycated
Site 61 – 61 Not glycated
Site 91 – 91 Not glycated
Glycosylation 62 – 62 N-linked (Glc) (glycation) lysine
Helix 77 – 80



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.