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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Pro96Thr

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 96
Type of variant: help LB/B
Residue change: help From Proline (P) to Threonine (T) at position 96 (P96T, p.Pro96Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to medium size and polar (T)
BLOSUM score: help -1
Variant description: help In Godavari; O(2) affinity up.
Other resources: help


Sequence information Variant position: help 96
Protein sequence length: help 142
Location on the sequence: help DMPNALSALSDLHAHKLRVD P VNFKLLSHCLLVTLAAHLPA
Residue conservation: help 
Human                         DMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

Gorilla                       DMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

                              DLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPT

Rhesus macaque                DMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

Chimpanzee                    DMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPA

Mouse                         DLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLASHHPA

Rat                           DLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPG

Pig                           DLPGALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHPD

Bovine                        DLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPS

Rabbit                        DLPGALSTLSDLHAHKLRVDPVNFKLLSHCLLVTLANHHPS

Sheep                         DLPGTLSDLSDLHAHKLRVDPVNFKLLSHSLLVTLACHLPN

Cat                           DLPTAMSALSDLHAYKLRVDPVNFKFLSHCLLVTLACHHPA

Horse                         DLPGALSNLSDLHAHKLRVDPVNFKLLSHCLLSTLAVHLPN

Chicken                       DIAGTLSKLSDLHAHKLRVDPVNFKLLGQCFLVVVAIHHPA

Xenopus tropicalis            NIAGCLSKLSDLHAYDLRVDPGNFPLLAHQILVVVAIHFPK

Zebrafish                     DLVGGLAALSELHAFKLRVDPANFKILSHNVIVVIAMLFPA
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Peptide 96 – 104 Hemopressin
Domain 2 – 142 Globin
Binding site 88 – 88 proximal binding residue
Site 91 – 91 Not glycated
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine



Literature citations
Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin.
Wajcman H.; Kister J.; Riou J.; Galacteros F.; Girot R.; Maier-Redelsperger M.; Nayudu N.V.S.; Giordano P.C.;
Hemoglobin 22:11-22(1998)
Cited for: VARIANT GODAVARI THR-96;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.