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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.His113Asp

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 113 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Histidine (H) to Aspartate (D) at position 113 (H113D, p.His113Asp). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (H) to medium size and acidic (D) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In Hopkins-II; unstable. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 113 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help RVDPVNFKLLSHCLLVTLAA H LPAEFTPAVHASLDKFLASV The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         RVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASV

Gorilla                       RVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASV

                              RVDPVNFKLLSHCLLVTLACHHPTEFTPAVHASLDKFFAAV

Rhesus macaque                RVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASV

Chimpanzee                    RVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASV

Mouse                         RVDPVNFKLLSHCLLVTLASHHPADFTPAVHASLDKFLASV

Rat                           RVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASV

Pig                           RVDPVNFKLLSHCLLVTLAAHHPDDFNPSVHASLDKFLANV

Bovine                        RVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANV

Rabbit                        RVDPVNFKLLSHCLLVTLANHHPSEFTPAVHASLDKFLANV

Sheep                         RVDPVNFKLLSHSLLVTLACHLPNDFTPAVHASLDKFLANV

Cat                           RVDPVNFKFLSHCLLVTLACHHPAEFTPAVHASLDKFFSAV

Horse                         RVDPVNFKLLSHCLLSTLAVHLPNDFTPAVHASLDKFLSSV

Chicken                       RVDPVNFKLLGQCFLVVVAIHHPAALTPEVHASLDKFLCAV

Xenopus tropicalis            RVDPGNFPLLAHQILVVVAIHFPKQFDPATHKALDKFLVSV

Zebrafish                     RVDPANFKILSHNVIVVIAMLFPADFTPEVHVSVDKFFNNL

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Domain 2 – 142 Globin
Site 100 – 100 Not glycated
Modified residue 103 – 103 Phosphoserine
Modified residue 109 – 109 Phosphothreonine
Modified residue 125 – 125 Phosphoserine
Modified residue 132 – 132 Phosphoserine
Helix 97 – 113



Literature citations
Clinical studies and physiological properties of Hopkins-2 haemoglobin.
Charache S.; Ostertag W.; von Ehrenstein G.;
Nature New Biol. 234:248-251(1971)
Cited for: VARIANT HOPKINS-II ASP-113;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.