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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P69905: Variant p.Ala131Asp

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 131
Type of variant: help LB/B
Residue change: help From Alanine (A) to Aspartate (D) at position 131 (A131D, p.Ala131Asp).
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and acidic (D)
BLOSUM score: help -2
Variant description: help In Yuda; O(2) affinity down.
Other resources: help


Sequence information Variant position: help 131
Protein sequence length: help 142
Location on the sequence: help AAHLPAEFTPAVHASLDKFL A SVSTVLTSKYR
Residue conservation: help
Human                         AAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Gorilla                       AAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

                              ACHHPTEFTPAVHASLDKFFAAVSTVLTSKYR

Rhesus macaque                AAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Chimpanzee                    AAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Mouse                         ASHHPADFTPAVHASLDKFLASVSTVLTSKYR

Rat                           ACHHPGDFTPAMHASLDKFLASVSTVLTSKYR

Pig                           AAHHPDDFNPSVHASLDKFLANVSTVLTSKYR

Bovine                        ASHLPSDFTPAVHASLDKFLANVSTVLTSKYR

Rabbit                        ANHHPSEFTPAVHASLDKFLANVSTVLTSKYR

Sheep                         ACHLPNDFTPAVHASLDKFLANVSTVLTSKYR

Cat                           ACHHPAEFTPAVHASLDKFFSAVSTVLTSKYR

Horse                         AVHLPNDFTPAVHASLDKFLSSVSTVLTSKYR

Chicken                       AIHHPAALTPEVHASLDKFLCAVGTVLTAKYR

Xenopus tropicalis            AIHFPKQFDPATHKALDKFLVSVSNVLTSKYR

Zebrafish                     AMLFPADFTPEVHVSVDKFFNNLALALSEKYR

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Domain 2 – 142 Globin
Modified residue 125 – 125 Phosphoserine
Modified residue 132 – 132 Phosphoserine
Modified residue 135 – 135 Phosphothreonine
Modified residue 138 – 138 Phosphothreonine
Modified residue 139 – 139 Phosphoserine
Helix 120 – 138



Literature citations
Hb Yuda or alpha 130(H13)Ala-->Asp; a new alpha chain variant with low oxygen affinity.
Fujisawa K.; Hattori Y.; Ohba Y.; Ando S.;
Hemoglobin 16:435-439(1992)
Cited for: VARIANT YUDA ASP-131;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.