Variant position: 109 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 204 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EISKQLGYQWKMLTEAEKWP FFQEAQKLQAMHREKYPNYKY
Gorilla EISKQLGYQWKMLTEAEKWP FFQEAQKLQAMHREKYPNYKY
Rhesus macaque EISKQLGYQWKMLTEADKWP FFQEAQKLQAMHREKYPNYKY
Chimpanzee EISKQLGYQWKMLTEAEKWP FFQEAQKLQAMHREKYPNYKY
Mouse EISKQLGCRWKSLTEAEKRP FFQEAQRLKILHREKYPNYKY
Pig EISKWLGCKWKMLTEAEKRP FFEEAQRLQAVHRDKYPGYKY
Bovine DISKQLGYEWKRLTDAEKRP FFEEAQRLLAIHRDKYPGYKY
Goat EISKQLGYEWKRLTDAEKRP FFEEAQRLLAIHRDKYPGYKY
Sheep EISKQLGYEWKRLTDAEKRP FFEEAQRLLAIHRDKYPGYKY
Cat EISKQLGYQWKMLTQAEKWP FFEEAQRLQALHREKYPGYRY
Horse EISKRLGCQWKMLTEAEKLP FFEEAQRLRAMHQEKYPDYKY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 204 Sex-determining region Y protein
60 – 128 HMG box
59 – 136 Sufficient for interaction with KPNB1
107 – 139 Sufficient for interaction with EP300
115 – 115 K -> R. Does not abolish acetylation activity.
123 – 123 K -> R. Does not abolish acetylation.
128 – 128 K -> R. Does not abolish acetylation.
103 – 123
A familial mutation in the testis-determining gene SRY shared by both sexes.
Jaeger R.J.; Harley V.R.; Pfeiffer R.A.; Goodfellow P.N.; Scherer G.;
Hum. Genet. 90:350-355(1992)
Cited for: VARIANT SRXY1 SER-109;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.