Variant position: 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 110 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GGGPGAGSLQPLALEGSLQK RGIVEQCCTSICSLYQLENYC
Gorilla GGGPGAGSLQPLALEGSLQK RGIVEQCCTSICSLYQLENYC
Chimpanzee GGGPGAGSLQPLALEGSLQK RGIVEQCCTSICSLYQLENYC
Pig GG--GLGGLQALALEGPPQK RGIVEQCCTSICSLYQLENYC
Bovine AGGPGAGGL-----EGPPQK RGIVEQCCASVCSLYQLENYC
Rabbit GGGPGAGGLQPSALELALQK RGIVEQCCTSICSLYQLENYC
Goat -------------------- -GIVEQCCAGVCSLYQLENYC
Sheep AGGPGAGGL-----EGPPQK RGIVEQCCAGVCSLYQLENYC
Cat GEAPGAGGLQPSALEAPLQK RGIVEQCCASVCSLYQLEHYC
Horse GGGPGLGGLQPLALAGPQQX XGIVEQCCTGICSLYQLENYC
Chicken GE---AGVLPFQQEEYEKVK RGIVEQCCHNTCSLYQLENYC
Zebrafish AQETEVADFAFKDHAELIRK RGIVEQCCHKPCSIFELQNYC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
31 – 96 Interchain (between B and A chains)
43 – 109 Interchain (between B and A chains)
A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).
Yano H.; Kitano N.; Morimoto M.; Polonsky K.S.; Imura H.; Seino Y.;
J. Clin. Invest. 89:1902-1907(1992)
Cited for: VARIANT HPRI LEU-89;
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