Variant position: 276 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 821 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PILQAGLPANASTVVGGDVE FVCKVYSDAQPHIQWIKHVEK
Mouse PILQAGLPANASTVVGGDVE FVCKVYSDAQPHIQWIKHVEK
Chicken PILQAGLPANASAVVGGDVE FVCKVYSDAQPHIQWIKHVER
Xenopus laevis PILQAGLPANTTAVVGGDAE FVCKVYSDAQPHIRWVRYIEK
Zebrafish PILQAGLPANVTVQVGQDAK FVCKVYSDAQPHIQWLQHYTK
Drosophila PIIV--VPQNQTVKVNGSLV MKCTVYSDLHPTVSWKRVVLK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 821 Fibroblast growth factor receptor 2
22 – 377 Extracellular
256 – 358 Ig-like C2-type 3
265 – 265 N-linked (GlcNAc...)
250 – 361 Missing. In isoform 23.
255 – 821 Missing. In isoform 14.
265 – 265 N -> Q. Reduced N-glycosylation. Reduced expression at the cell surface.
274 – 277
No reference for the current variant in UniProtKB/Swiss-Prot.
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