Variant position: 222 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 332 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SGMNVAGVSLKTLHPDLGTD KDKEQWKEVHKQVVESAYEVI
Chimpanzee SGMNVAGVSLKTLHPDLGTD KDKEQWKEVHKQVVESAYEVI
Mouse SGVNVAGVSLKSLNPELGTD ADKEQWKEVHKQVVDSAYEVI
Rat SGVNVAGVSLKSLNPQLGTD ADKEQWKDVHKQVVDSAYEVI
Pig SGVNVAGVSLKNLHPELGTD ADKEHWKAVHKQVVDSAYEVI
Bovine SGVNVAGVSLKNLHPELGTD ADKEQWKAVHKQVVDSAYEVI
Rabbit SGMNVAGVSLKTLHPELGTD ADKEQWKQVHKQVVDSAYEVI
Chicken SGVNVAGVSLKALHPDMGTD ADKEHWKEVHKQVVDSAYEVI
Xenopus laevis SGVNVAGVSLQSLKPDIGTD EDCCKWKEVHKQVVDSAYEVI
Zebrafish SGVNVAGVSLQALNPDLGTD KDKEDWKSVHKMVVDSAYEVI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 332 L-lactate dehydrogenase A chain
239 – 239 Phosphotyrosine
220 – 222
Suzuki Y.; Sugano S.; Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT GLU-222;
Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes.
Maekawa M.; Sudo K.; Kobayashi A.; Sugiyama E.; Li S.S.-L.; Kanno T.;
Clin. Chem. 40:665-668(1994)
Cited for: VARIANT GLU-222;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.