Variant position: 315 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 332 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LGQNGISDLVKVTLTSEEEA RLKKSADTLWGIQKELQ-F
Chimpanzee LGQNGISDLVKVTLTSEEEA RLKKSADTLWGIQKELQ-
Mouse LGQNGISDVVKVTLTPEEEA RLKKSADTLWGIQKELQ-
Rat LGQNGISDVVKVTLTPDEEA RLKKSADTLWGIQKELQ-
Pig LGQNGISDVVKVTLTPEEEA HLKKSADTLWGIQKELQ-
Bovine LGQNGISDVVKVTLTHEEEA CLKKSADTLWGIQKELQ-
Rabbit LGQNGISDVVKVTLTSEEEA HLKKSADTLWGIQKELQ-
Chicken LGSSGITDVVKMILKPDEEE KIKKSADTLWGIQKELQ-
Xenopus laevis LNGNGLTSVINQKLKDNEVG QLQKSAETLWSIQKDLKD
Zebrafish LGNNGLTDVVHMTLKPEEEK QLVKSAETLWGVQKELT-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 332 L-lactate dehydrogenase A chain
309 – 309 Phosphothreonine
310 – 310 Phosphoserine
318 – 318 N6-acetyllysine; alternate
318 – 318 N6-succinyllysine; alternate
322 – 322 Phosphothreonine
242 – 332 Missing. In isoform 5.
275 – 332 Missing. In isoform 2.
310 – 327
Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit.
Sudo K.; Maekawa M.; Shioya M.; Ikeda K.; Takahashi N.; Isogai Y.; Li S.S.-L.; Kanno T.; Machida K.; Toriumi J.;
Biochem. Int. 27:1051-1057(1992)
Cited for: VARIANT CYS-315;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.