Variant position: 31 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 359 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PLRE---VSGLLKRRFHWTAP----AA LQVTVRDAINQGMDEELERDE
Mouse PLRQ---ASGLLKRRFHRSAP----AA VQLTVREAINQGMD
Rat PLRQ---ASGLLKRRFHRSAP----AA VQLTVREAINQGMD
Bovine PLEQ---VSGLLRRRFHRTAP----AA LQVTVREAINQGMD
Caenorhabditis elegans ALRK---CGNLFVARLAGTST---RAA STMTVRDALNQAMD
Slime mold ILKK---IQPSLLVNFRIITRT--YAT KEVTVRDAINSALD
Baker's yeast VARR---APTSFVRPSAAAAALRFSST KTMTVREALNSAMA
Fission yeast TSRSWKLLSSTIAKRYSSSSN----GV KEMTVRDALNSAME
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
31 – 359 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
16 – 33 Missing. In isoform 2.
Characterization of two cDNA clones for pyruvate dehydrogenase E1 beta subunit and its regulation in tricarboxylic acid cycle-deficient fibroblast.
Huh T.L.; Casazza J.P.; Huh J.W.; Chi Y.T.; Song B.J.;
J. Biol. Chem. 265:13320-13326(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT VAL-31;
Cloning and sequencing of cDNAs encoding alpha and beta subunits of human pyruvate dehydrogenase.
Koike K.; Ohta S.; Urata Y.; Kagawa Y.; Koike M.;
Proc. Natl. Acad. Sci. U.S.A. 85:41-45(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT VAL-31;
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