Variant position: 72 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 195 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LEYPRGKRKKGSTMERWGQK YMTAVVKLFGPFT---RNYYVRAV
Mouse LEYPRGKRKKGSTMERCGQK YLTSVVKLFGPLT---RNYYV
Rat LEYPRGKRKKGSTMERCGQK YLTAVVKLFGPLT---RNYYV
Pig LEYPRGRRTKGSTMERCEQK YMTKVVKAFGPLS---RNYYI
Bovine LEYPRGKRSKGSTMERCGQK YLTRVVKLFGPLT---RNYYI
Rabbit LEYPRGSRAKGSTLERCGQR YLTAVLKLLGPLS---RNYYF
Slime mold LLYP---------------- -----LSFLGPLKAIFHQYYV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 195 Cytochrome b-245 light chain
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
Parkos C.A.; Dinauer M.C.; Walker L.E.; Allen R.A.; Jesaitis A.J.; Orkin S.H.;
Proc. Natl. Acad. Sci. U.S.A. 85:3319-3323(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PROTEIN SEQUENCE OF 2-26; VARIANTS HIS-72 AND ALA-174;
Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils.
Verhoeven A.J.; Bolscher B.G.; Meerhof L.J.; van Zwieten R.; Keijer J.; Weening R.S.; Roos D.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-195; VARIANTS HIS-72 AND ALA-174;
Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation.
Bedard K.; Attar H.; Bonnefont J.; Jaquet V.; Borel C.; Plastre O.; Stasia M.-J.; Antonarakis S.E.; Krause K.-H.;
Hum. Mutat. 30:1123-1133(2009)
Cited for: VARIANTS HIS-72; GLY-171; ALA-174 AND ASP-193;
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