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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P08581: Variant p.Asp1228Asn

Hepatocyte growth factor receptor
Gene: MET
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Variant information Variant position: help 1228 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Aspartate (D) to Asparagine (N) at position 1228 (D1228N, p.Asp1228Asn). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (N) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In RCCP; germline mutation. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 1228 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1390 The length of the canonical sequence.
Location on the sequence: help RNCMLDEKFTVKVADFGLAR D MYDKEYYSVHNKTGAKLPVK The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 25 – 1390 Hepatocyte growth factor receptor
Topological domain 956 – 1390 Cytoplasmic
Domain 1078 – 1345 Protein kinase
Region 1212 – 1390 Interaction with RANBP9
Modified residue 1230 – 1230 Phosphotyrosine
Modified residue 1234 – 1234 Phosphotyrosine; by autocatalysis
Modified residue 1235 – 1235 Phosphotyrosine; by autocatalysis
Alternative sequence 765 – 1390 Missing. In isoform 3.
Mutagenesis 1234 – 1234 Y -> F. Complete loss of kinase activity and of ligand-induced ubiquitination. Alters interaction with PTPN1 and PTPN2. Loss of interaction with PTPN1 and PTPN2; when associated with F-1235.
Mutagenesis 1235 – 1235 Y -> F. Complete loss of kinase activity. Alters interaction with PTPN1 and PTPN2. Loss of interaction with PTPN1 and PTPN2; when associated with F-1234.
Turn 1227 – 1230



Literature citations
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.
Schmidt L.; Duh F.-M.; Chen F.; Kishida T.; Glenn G.; Choyke P.; Scherer S.W.; Zhuang Z.; Lubensky I.; Dean M.; Allikmets R.; Chidambaram A.; Bergerheim U.R.; Feltis J.T.; Casadevall C.; Zamarron A.; Bernues M.; Richard S.; Lips C.J.M.; Walther M.M.; Tsui L.-C.; Geil L.; Orcutt M.L.; Stackhouse T.; Lipan J.; Slife L.; Brauch H.; Decker J.; Niehans G.; Hughson M.D.; Moch H.; Storkel S.; Lerman M.I.; Linehan W.M.; Zbar B.;
Nat. Genet. 16:68-73(1997)
Cited for: VARIANTS RCCP THR-1131; LEU-1188; VAL-1195; ILE-1220; HIS-1228; ASN-1228; CYS-1230; HIS-1230 AND THR-1250; VARIANT VAL-320;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.