Variant position: 158 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 427 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QSLMCGHQDVMVAGGMESMS NVPYVM--NRGSTPYGGVKLEDL
Mouse QSLMCGHQDVMVAGGMESMS NVPYVM--SRGATPYGGVKLE
Rat QSLMCGHQDVMVAGGMESMS NVPYVM--SRGATPYGGVKLE
Bovine QNLMCGHQDVMVAGGMESMS NVPYVM--NRGATPYGGVKLE
Xenopus tropicalis QSLMCGHQQVMVAGGMESMS NVPYCM--SRGATPYGGVKLE
Zebrafish QSLMCGHQDVMVAGGMESMS QVPYIM--AREAPPYGGVKME
Baker's yeast QSIKCGNADVVVAGGCESMT NAPYYMPAARAGAKFGQTVLV
Fission yeast QTIMTGNAEIVVAGGTESMS NAPYYAPKNRFGAKYGNVELV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
34 – 427 Acetyl-CoA acetyltransferase, mitochondrial
174 – 174 N6-acetyllysine; alternate
174 – 174 N6-succinyllysine; alternate
156 – 158
Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients.
Wakazono A.; Fukao T.; Yamaguchi S.; Hori T.; Orii T.; Lambert M.; Mitchell G.A.; Lee G.W.; Hashimoto T.;
Hum. Mutat. 5:34-42(1995)
Cited for: VARIANTS 3KTD ASP-158; MET-297 AND PRO-301;
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