Variant position: 131 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 147 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AEVVFTANDSGPRRYTIAAL LSPYSYSTTAVVTNPKE---
Chimpanzee AEVVFTANDSGPRRYTIAAL LSPYSYSTTAVVTIPKE
Mouse ADVVFTANDSGHRHYTIAAL LSPYSYSTTAVVSNPQN
Rat AEVVFTANDSGHRHYTIAAL LSPYSYSTTAVVSNPQN
Pig AEVVFTANDSGRRHYTIAAL LSPYSYSTTALVSSPKE
Bovine AEVVFTANDSGPRHYTIAAL LSPYSYSTTALVSSPKA
Rabbit AEVVFTANDSGHRSYTIAAL LSPFSYSTTAVVSNPQE
Sheep AEVVFTANDSGLRHYTIAAL LSPYSYSTTALVSSPKE
Chicken ADVVFTANDSGHRHYTIAAL LSPFSYSTTAVVSDPQE
Xenopus laevis VDVVFTANDAGHRHYTIAVL LTPYSFSSTAIVSEPHD
Xenopus tropicalis VDVVFSANDAGHRHYTIAVL LTPYSISSTAVVSEPHD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
21 – 147 Transthyretin
118 – 118 N-linked (GlcNAc...)
130 – 130 L -> M. Loss of tetramerization; when associated with M-107.
124 – 132
No reference for the current variant in UniProtKB/Swiss-Prot.
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