Variant position: 147 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 339 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EDVRIFFYQSPYDSEQVPQA LRRLRPRTRKVKSVSPQGNSV
Mouse PDVRIFFYQSAYDAEQVPQA LRRLRPRTRKIKGVSPQGAIM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 339 Neutrophil cytosol factor 4
154 – 154 Phosphothreonine
154 – 154 T -> A. Reduces phosphorylation.
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains.
Wientjes F.B.; Hsuan J.J.; Totty N.F.; Segal A.W.;
Biochem. J. 296:557-561(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; SUBUNIT; SUBCELLULAR LOCATION; VARIANT ILE-147; PARTIAL PROTEIN SEQUENCE;
Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex.
Zhan S.; Vazquez N.; Zhan S.; Wientjes F.B.; Budarf M.L.; Schrock E.; Ried T.; Green E.D.; Chanock S.J.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ILE-147;
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