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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P10275: Variant p.Lys631Thr

Androgen receptor
Gene: AR
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Variant information Variant position: help 631 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Lysine (K) to Threonine (T) at position 631 (K631T, p.Lys631Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (K) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In prostate cancer. Any additional useful information about the variant.


Sequence information Variant position: help 631 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 920 The length of the canonical sequence.
Location on the sequence: help NCPSCRLRKCYEAGMTLGAR K LKKLGNLKLQEEGEASSTTS The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTS

                              NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASNVTS

Rhesus macaque                NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTS

Chimpanzee                    NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTS

Mouse                         NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGS

Rat                           NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSSAGS

Pig                           NCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSATS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 920 Androgen receptor
DNA binding 560 – 632 Nuclear receptor
Region 552 – 919 Interaction with LPXN
Region 572 – 662 Interaction with HIPK3
Region 592 – 919 Interaction with CCAR1
Region 625 – 919 Interaction with KAT7
Modified residue 651 – 651 Phosphoserine; by STK4/MST1
Alternative sequence 629 – 644 ARKLKKLGNLKLQEEG -> EKFRVGNCKHLKMTRP. In isoform 3.
Alternative sequence 630 – 648 RKLKKLGNLKLQEEGEASS -> AVVVSERILRVFGVSEWLP. In isoform 4.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.