Variant position: 15 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 198 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MSNVRVSNGSPSLE RMDARQAEHPKPSACRNLFGP
Mouse MSNVRVSNGSPSLE RMDARQAEHPKPSACRNLFGP
Cat MSNVRVSNGSPSLE RMDARQAEYPKPSACRNLFGP
Dog MSNVRVSNGSPTSE RRDAKQAEYPKPSACRNLFGP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 198 Cyclin-dependent kinase inhibitor 1B
10 – 10 Phosphoserine; by UHMK1
10 – 10 S -> A. Loss of phosphorylation by UHMK1. No translocation to the cytoplasm. Greater cell cycle arrest.
10 – 10 S -> D. Exported to the cytoplasm. Inhibits cell cycle arrest.
10 – 10 S -> E. Increased stability in vivo and in vitro.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS TRP-15 AND GLY-109;
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