Variant position: 109 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 198 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YRPPRPPKGACKVPAQESQD VSGSRPAAPLIGAPANSEDTH
Mouse YRPPRPPKSACKVLAQESQD VSGSRQAVPLIGSQANSEDRH
Cat YRPPRPPKGACKVPAQESQD VSGNRQAVPLIGSQANTEDTH
Dog YRPPRPPKGACKVPAQESQD VSGTRQAGPLLGSQANSEDTH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 198 Cyclin-dependent kinase inhibitor 1B
89 – 89 Phosphotyrosine
89 – 89 Y -> F. No effect on binding CDK2 complexes, reduced CDK4 binding and greatly inhibits CDK4 enzyme activity. No nuclear translocation. Inhibits in vitro phosphorylation of CDK4 by CCNH-CDK7. Completely abolishes CDK4 binding; when associated with F-88.
No reference for the current variant in UniProtKB/Swiss-Prot.
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