Variant position: 94 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 233 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AQ--AVRSSSRTPSDKPVAHVV ANPQAEGQLQWLNRRANALLA
Rhesus macaque AQ--AVRSSSRTPSDKPVAHVV ANPQAEGQLQWLNRRANAL
Chimpanzee AQ---AGSSSRTPSDKPVAHVV ANPQAEGQLQWLNRRANAL
Mouse AQTLTLRSSSQNSSDKPVAHVV ANHQVEEQLEWLSQRANAL
Rat AQTLTLRSSSQNSSDKPVAHVV ANHQAEEQLEWLSQRANAL
Pig AQ--GLRSSSQT-SDKPVAHVV ANVKAEGQLQWQSGYANAL
Bovine VQ--TLRSSSQASSNKPVAHVV ADINSPGQLRWWDSYANAL
Rabbit AQMVTLRSASRALSDKPLAHVV ANPQVEGQLQWLSQRANAL
Goat VQ--TLRSSSQASSNKPVAHVV ANISAPGQLRWGDSYANAL
Sheep VQ--TLRSSSQASNNKPVAHVV ANISAPGQLRWGDSYANAL
Cat PQ--TLRSSSRTPSDKPVAHVV ANPEAEGQLQWLSRRANAL
Horse AQ--TLRSSSRTPSDKPVAHVV ANPQAEGQLQWLSGRANAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 233 Tumor necrosis factor, membrane form
77 – 233 Tumor necrosis factor, soluble form
57 – 233 Extracellular
80 – 80 O-linked (GalNAc...); in soluble form
105 – 105 L -> S. Low activity.
108 – 108 R -> W. Biologically inactive.
112 – 112 L -> F. Biologically inactive.
89 – 94
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.