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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O60858: Variant p.Ser355Thr

E3 ubiquitin-protein ligase TRIM13
Gene: TRIM13
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Variant information Variant position: help 355 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Threonine (T) at position 355 (S355T, p.Ser355Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 355 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 407 The length of the canonical sequence.
Location on the sequence: help FLEWSLFDDLATWKGCLSNF S SYLTKTADFIEQSVFYWEQV The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         FLEWSLFDDLA-TWKGCLSNFSSY-LTKTADFIEQSVFYWEQV

Mouse                         FLEWSPLDELA-TWKDYLSSFNSY-LTKSADFIEQSVFYWE

Rat                           FLEWSPLEELA-TWKDCLSSFNSY-LTKSADFVEQSVFYWE

Bovine                        FLEWSLFDEIA-TWKDNLSNFSSY-LTRSADFVEQSVFYWE

Xenopus tropicalis            FIDSLP------TFTIDLQVISSYFFTTTAKAANLTILFWE

Zebrafish                     ALNFLPSDCLALSFQDKVVALGGFSLPSPGEIVRWLGFCWK

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 407 E3 ubiquitin-protein ligase TRIM13
Alternative sequence 176 – 407 Missing. In isoform 2.



Literature citations
A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5.
Kapanadze B.; Kashuba V.; Baranova A.; Rasool O.; van Everdink W.J.; Liu Y.; Syomov A.; Corcoran M.; Poltaraus A.; Brodyansky V.; Syomova N.; Kazakov A.; Ibbotson R.; van den Berg A.; Gizatullin R.; Fedorova L.; Sulimova G.; Zelenin A.; Deaven L.; Lehrach H.; Grander D.; Buys C.; Oscier D.; Zabarovsky E.R.; Einhorn S.; Yankovsky N.;
FEBS Lett. 426:266-270(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT THR-355; The tripartite motif family identifies cell compartments.
Reymond A.; Meroni G.; Fantozzi A.; Merla G.; Cairo S.; Luzi L.; Riganelli D.; Zanaria E.; Messali S.; Cainarca S.; Guffanti A.; Minucci S.; Pelicci P.G.; Ballabio A.;
EMBO J. 20:2140-2151(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT THR-355; RFP2 putative tumor suppressor gene: genomic organization, multiple mRNA isoforms and evaluation as a B-cell chronic lymphocytic leukaemia candidate.
Baranova A.V.; Sangfelt O.; Ivanov D.V.; Borodina T.A.; Yankovsky N.K.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1); VARIANT THR-355; The DNA sequence and analysis of human chromosome 13.
Dunham A.; Matthews L.H.; Burton J.; Ashurst J.L.; Howe K.L.; Ashcroft K.J.; Beare D.M.; Burford D.C.; Hunt S.E.; Griffiths-Jones S.; Jones M.C.; Keenan S.J.; Oliver K.; Scott C.E.; Ainscough R.; Almeida J.P.; Ambrose K.D.; Andrews D.T.; Ashwell R.I.S.; Babbage A.K.; Bagguley C.L.; Bailey J.; Bannerjee R.; Barlow K.F.; Bates K.; Beasley H.; Bird C.P.; Bray-Allen S.; Brown A.J.; Brown J.Y.; Burrill W.; Carder C.; Carter N.P.; Chapman J.C.; Clamp M.E.; Clark S.Y.; Clarke G.; Clee C.M.; Clegg S.C.; Cobley V.; Collins J.E.; Corby N.; Coville G.J.; Deloukas P.; Dhami P.; Dunham I.; Dunn M.; Earthrowl M.E.; Ellington A.G.; Faulkner L.; Frankish A.G.; Frankland J.; French L.; Garner P.; Garnett J.; Gilbert J.G.R.; Gilson C.J.; Ghori J.; Grafham D.V.; Gribble S.M.; Griffiths C.; Hall R.E.; Hammond S.; Harley J.L.; Hart E.A.; Heath P.D.; Howden P.J.; Huckle E.J.; Hunt P.J.; Hunt A.R.; Johnson C.; Johnson D.; Kay M.; Kimberley A.M.; King A.; Laird G.K.; Langford C.J.; Lawlor S.; Leongamornlert D.A.; Lloyd D.M.; Lloyd C.; Loveland J.E.; Lovell J.; Martin S.; Mashreghi-Mohammadi M.; McLaren S.J.; McMurray A.; Milne S.; Moore M.J.F.; Nickerson T.; Palmer S.A.; Pearce A.V.; Peck A.I.; Pelan S.; Phillimore B.; Porter K.M.; Rice C.M.; Searle S.; Sehra H.K.; Shownkeen R.; Skuce C.D.; Smith M.; Steward C.A.; Sycamore N.; Tester J.; Thomas D.W.; Tracey A.; Tromans A.; Tubby B.; Wall M.; Wallis J.M.; West A.P.; Whitehead S.L.; Willey D.L.; Wilming L.; Wray P.W.; Wright M.W.; Young L.; Coulson A.; Durbin R.M.; Hubbard T.; Sulston J.E.; Beck S.; Bentley D.R.; Rogers J.; Ross M.T.;
Nature 428:522-528(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT THR-355;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.