UniProtKB/Swiss-Prot Q9Y6L6: Variant p.Arg152Lys

Solute carrier organic anion transporter family member 1B1
Gene: SLCO1B1
Chromosomal location: 12p12.1
Variant information

Variant position:  152
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants have been found in patients and disease-association is reported in literature. However, this classification is not a definitive assessment of variant pathogenicity.
  • Polymorphism: No disease-association has been reported.
  • Unclassified: Variants have been found in patients but disease-association remains unclear.

Residue change:  From Arginine (R) to Lysine (K) at position 152 (R152K, p.Arg152Lys).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are large size and basic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page



Sequence information

Variant position:  152
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  691
The length of the canonical sequence.

Location on the sequence:   SENSTSTLSTCLINQILSLN  R ASPEIVGKGCLKESGSYMWI
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 691 Solute carrier organic anion transporter family member 1B1
Topological domain 120 – 168 Extracellular
Glycosylation 134 – 134 N-linked (GlcNAc...)


Literature citations

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.
Abe T.; Kakyo M.; Tokui T.; Nakagomi R.; Nishio T.; Nakai D.; Nomura H.; Unno M.; Suzuki M.; Naitoh T.; Matsuno S.; Yawo H.;
J. Biol. Chem. 274:17159-17163(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; TISSUE SPECIFICITY; VARIANTS LYS-152 AND ASN-241;

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans.
Tirona R.G.; Leake B.F.; Merino G.; Kim R.B.;
J. Biol. Chem. 276:35669-35675(2001)
Cited for: VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174; ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667; CHARACTERIZATION;

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.
Nozawa T.; Nakajima M.; Tamai I.; Noda K.; Nezu J.; Sai Y.; Tsuji A.; Yokoi T.;
J. Pharmacol. Exp. Ther. 302:804-813(2002)
Cited for: VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.