Variant position: 196 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TDICRPHQICNVVAIPGNAS MDAVCTSTSPTRSMAPGAVHL
Mouse TDVCRPHRICSILAIPGNAS TDAVCAPESPTLSAIPRTLYV
Rat TDVCRPHRICSILAIPGNAS TDAVCASESPTPSAVPRTIYV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
23 – 461 Tumor necrosis factor receptor superfamily member 1b, membrane form
23 – 257 Extracellular
163 – 201 TNFR-Cys 4
193 – 193 N-linked (GlcNAc...)
194 – 196
A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.
Kohno T.; Brewer M.T.; Baker S.L.; Schwartz P.E.; King M.W.; Hale K.K.; Squires C.H.; Thompson R.C.; Vannice J.L.;
Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ARG-196;
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS MET-187; ARG-196; LYS-232; THR-236; PRO-264 AND ARG-295;
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-196; LYS-232; PRO-269 AND ARG-301;
Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor.
Heller R.A.; Song K.; Onasch M.A.; Fischer W.H.; Chang D.; Ringold G.M.;
Proc. Natl. Acad. Sci. U.S.A. 87:6151-6155(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 116-461 (ISOFORM 1); PARTIAL PROTEIN SEQUENCE; VARIANT ARG-196;
New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus.
Tsuchiya N.; Komata T.; Matsushita M.; Ohashi J.; Tokunaga K.;
Genes Immun. 1:501-503(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 154-183; VARIANTS ARG-196 AND LYS-232;
Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis.
Morita C.; Horiuchi T.; Tsukamoto H.; Hatta N.; Kikuchi Y.; Arinobu Y.; Otsuka T.; Sawabe T.; Harashima S.; Nagasawa K.; Niho Y.;
Arthritis Rheum. 44:2819-2827(2001)
Cited for: VARIANTS ARG-196 AND LYS-232;
Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.
Peral B.; San Millan J.L.; Castello R.; Moghetti P.; Escobar-Morreale H.F.;
J. Clin. Endocrinol. Metab. 87:3977-3983(2002)
Cited for: VARIANT ARG-196;
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