Variant position: 12 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 189 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MTEYKLVVVGA GGVGKSALTIQLIQNHFVDEY
Mouse MTEYKLVVVGA GGVGKSALTIQLIQNHFVDEY
Rat MTEYKLVVVGA GGVGKSALTIQLIQNHFVDEY
Xenopus laevis MTEYKLVVVGA VGVGKSALTIQLIQNHFVDEY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 186 GTPase KRas
1 – 1 Removed; alternate
2 – 186 GTPase KRas, N-terminally processed
10 – 18 GTP
1 – 1 N-acetylmethionine; in GTPase KRas; alternate
2 – 2 N-acetylthreonine; in GTPase KRas, N-terminally processed
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.
Santos E.; Martin-Zanca D.; Reddy P.E.; Pierotti M.A.; Porta G.; Barbacid M.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36; VARIANT BLADDER/LUNG CANCER ARG-12;
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