Variant position: 448 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LPERFLTPDGAIDKVLSEKV IIFGMGKRKCIGETIARWEVF
Rhesus macaque LPERFITPDGAIDKVLSEKV ILFGLGKRKCIGETIARWEVF
Mouse RPERFLTPSGTLDKRLSEKV TLFGLGKRKCIGETIGRSEVF
Rat RPERFLTSSGTLDKHLSEKV ILFGLGKRKCIGETIGRLEVF
Rabbit RPERFLTPSGAVDKALTEKV LLFGLGKRKCIGETIGRLEVF
Sheep RPERFLTTDGTVNKVLSEKV IIFGLGKRQCIGEIIARLEVF
Cat RPERFLTPDGTINKALSEKV ILFGLGKRKCIGETIARLEVF
Dog QPERFLTLDGTINKALSEKV ILFGLGKRKCIGETIARLEVF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 512 Cytochrome P450 1A1
457 – 457 Iron (heme axial ligand)
190 – 512 Missing. In isoform 2.
419 – 512 Missing. In isoform 3.
Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.
Saito M.; Egashira M.; Kiyotani K.; Fujieda M.; Yamazaki H.; Kiyohara C.; Kunitoh H.; Kamataki T.;
Drug Metab. Pharmacokinet. 18:218-222(2003)
Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.