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UniProtKB/Swiss-Prot P04798: Variant p.Ile448Asn

Cytochrome P450 1A1
Gene: CYP1A1
Chromosomal location: 15q22-q24
Variant information

Variant position:  448
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Isoleucine (I) to Asparagine (N) at position 448 (I448N, p.Ile448Asn).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and hydrophobic (I) to medium size and polar (N)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -3
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In allele CYP1A1*8.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  448
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  512
The length of the canonical sequence.

Location on the sequence:   LPERFLTPDGAIDKVLSEKV  I IFGMGKRKCIGETIARWEVF
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF

                              QPERFLTLDGTINKALSEKVILFGLGKRKCIGETIARLEVF

Rhesus macaque                LPERFITPDGAIDKVLSEKVILFGLGKRKCIGETIARWEVF

Mouse                         RPERFLTPSGTLDKRLSEKVTLFGLGKRKCIGETIGRSEVF

Rat                           RPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVF

Rabbit                        RPERFLTPSGAVDKALTEKVLLFGLGKRKCIGETIGRLEVF

Sheep                         RPERFLTTDGTVNKVLSEKVIIFGLGKRQCIGEIIARLEVF

Cat                           RPERFLTPDGTINKALSEKVILFGLGKRKCIGETIARLEVF

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 512 Cytochrome P450 1A1
Metal binding 457 – 457 Iron (heme axial ligand)
Alternative sequence 190 – 512 Missing. In isoform 2.
Alternative sequence 419 – 512 Missing. In isoform 3.


Literature citations

Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.
Saito M.; Egashira M.; Kiyotani K.; Fujieda M.; Yamazaki H.; Kiyohara C.; Kunitoh H.; Kamataki T.;
Drug Metab. Pharmacokinet. 18:218-222(2003)
Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.