Variant position: 464 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SEKVIIFGMGKRKCIGETIA RWEVFLFLAILLQRVEFSVPL
Rhesus macaque SEKVILFGLGKRKCIGETIA RWEVFLFLAILLQRVEFSVPP
Mouse SEKVTLFGLGKRKCIGETIG RSEVFLFLAILLQQIEFKVSP
Rat SEKVILFGLGKRKCIGETIG RLEVFLFLAILLQQMEFNVSP
Rabbit TEKVLLFGLGKRKCIGETIG RLEVFLFLATLLQQVEFSVSP
Sheep SEKVIIFGLGKRQCIGEIIA RLEVFLFLAILLHQVEFHVTP
Cat SEKVILFGLGKRKCIGETIA RLEVFLFLAILLQQVEFSVPQ
Dog SEKVILFGLGKRKCIGETIA RLEVFLFLAILLQQVEFSVPE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 512 Cytochrome P450 1A1
457 – 457 Iron (heme axial ligand)
190 – 512 Missing. In isoform 2.
419 – 512 Missing. In isoform 3.
460 – 477
Novel nonsynonymous polymorphisms of the CYP1A1 Gene in Japanese.
Saito M.; Egashira M.; Kiyotani K.; Fujieda M.; Yamazaki H.; Kiyohara C.; Kunitoh H.; Kamataki T.;
Drug Metab. Pharmacokinet. 18:218-222(2003)
Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492;
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