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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P35222: Variant p.Ser33Tyr

Catenin beta-1
Gene: CTNNB1
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Variant information Variant position: help 33 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Tyrosine (Y) at position 33 (S33Y, p.Ser33Tyr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to large size and aromatic (Y) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In colorectal cancer and PTR; constitutively active Wnt signaling pathway; enhances transactivation of target genes. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 33 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 781 The length of the canonical sequence.
Location on the sequence: help AMEPDRKAAVSHWQQQSYLD S GIHSGATTTAPSLSGKGNPE The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         AMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

                              AMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

Mouse                         AMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

Rat                           AMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

Bovine                        AMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

Xenopus laevis                AMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

Zebrafish                     AMDPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPE

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 781 Catenin beta-1
Modified residue 23 – 23 Phosphoserine; by GSK3-beta; alternate
Modified residue 29 – 29 Phosphoserine; by GSK3-beta
Modified residue 33 – 33 Phosphoserine; by GSK3-beta and HIPK2
Modified residue 37 – 37 Phosphoserine; by GSK3-beta and HIPK2
Modified residue 41 – 41 Phosphothreonine; by GSK3-beta
Modified residue 45 – 45 Phosphoserine
Modified residue 49 – 49 N6-acetyllysine
Glycosylation 23 – 23 O-linked (GlcNAc) serine; alternate
Mutagenesis 29 – 29 S -> F. No effect.



Literature citations
Identification of two novel regulated serines in the N-terminus of beta-catenin.
van Noort M.; van de Wetering M.; Clevers H.;
Exp. Cell Res. 276:264-272(2002)
Cited for: PHOSPHORYLATION AT SER-23 AND SER-29 BY GSK3B; PHOSPHORYLATION AT THR-41; MUTAGENESIS OF SER-29; CHARACTERIZATION OF VARIANTS HEPATOCELLULAR CARCINOMA ARG-23; ALA-37 AND ALA-41; CHARACTERIZATION OF VARIANT PTR TYR-33; CHARACTERIZATION OF VARIANT MDB ALA-37; CHARACTERIZATION OF VARIANT DESMOID TUMOR ALA-41; CHARACTERIZATION OF VARIANT HEPATOBLASTOMA ALA-41; Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6.
Palka-Hamblin H.L.; Gierut J.J.; Bie W.; Brauer P.M.; Zheng Y.; Asara J.M.; Tyner A.L.;
J. Cell Sci. 123:236-245(2010)
Cited for: PHOSPHORYLATION AT TYR-64; TYR-142; TYR-331 AND TYR-333; INTERACTION WITH PTK6; MUTAGENESIS OF TYR-64; Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation.
Yang W.; Xia Y.; Ji H.; Zheng Y.; Liang J.; Huang W.; Gao X.; Aldape K.; Lu Z.;
Nature 480:118-122(2011)
Cited for: INTERACTION WITH PKM ISOFORM M2; PHOSPHORYLATION AT TYR-333; MUTAGENESIS OF TYR-333; Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-beta-Catenin Signaling Axis.
Higashimori A.; Dong Y.; Zhang Y.; Kang W.; Nakatsu G.; Ng S.S.M.; Arakawa T.; Sung J.J.Y.; Chan F.K.L.; Yu J.;
Cancer Res. 78:1643-1656(2018)
Cited for: INTERACTION WITH IRF2BPL; VARIANT TYR-33; Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Morin P.J.; Sparks A.B.; Korinek V.; Barker N.; Clevers H.; Vogelstein B.; Kinzler K.W.;
Science 275:1787-1790(1997)
Cited for: VARIANTS COLORECTAL CANCER TYR-33 AND SER-45 DEL; A common human skin tumour is caused by activating mutations in beta-catenin.
Chan E.F.; Gat U.; McNiff J.M.; Fuchs E.;
Nat. Genet. 21:410-413(1999)
Cited for: VARIANTS PTR GLY-32; TYR-32; PHE-33; TYR-33; GLU-34; CYS-37; PHE-37 AND ILE-41;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.