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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P06401: Variant p.Gln536Pro

Progesterone receptor
Gene: PGR
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Variant information Variant position: help 536 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glutamine (Q) to Proline (P) at position 536 (Q536P, p.Gln536Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (Q) to medium size and hydrophobic (P) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 536 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 933 The length of the canonical sequence.
Location on the sequence: help GLNGLPQLGYQAAVLKEGLP Q VYPPYLNYLRPDSEASQSPQ The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         GLNGLPQ-LGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQ

Gorilla                       GLNGLPQ-LGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSP

                              GLGALPQ-LGYQAAVLKEGLPQVYQPYLNYLRPDSDASQSP

Chimpanzee                    GLNGLPQ-LGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSP

Mouse                         GLNGLPQ-LGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSP

Rat                           GLNGLPQ-LGYQAAVLKDSLPQVYPPYLNYLRPDSEASQSP

Rabbit                        GLNGLPQ-LGYQAAVLKEGLPQVYTPYLNYLRPDSEASQSP

Chicken                       GLNGHHQALGFPAAVLKEGLPQLCPPYLGYVRPDTETSQSS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 933 Progesterone receptor
Region 1 – 566 Modulating, Pro-Rich
Region 456 – 546 AF1; mediates transcriptional activation
Cross 531 – 531 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Alternative sequence 1 – 594 Missing. In isoform 3.
Alternative sequence 17 – 635 Missing. In isoform 4.
Mutagenesis 531 – 531 K -> R. Some loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-388.



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-50; VAL-120; LEU-186; ARG-301; THR-344; SER-444; LEU-529; PRO-536; VAL-651 AND LEU-865;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.