Variant position: 266 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SDCLVCRKFRDEATCKDTCP PLMLYNPTTYQMDVNPEGKYS
Rhesus macaque SDCLVCRKFRDEATCKDTCP PLMLYNPTTYQMDVNPEGKYS
Mouse SDCLVCQKFQDEATCKDTCP PLMLYNPTTYQMDVNPEGKYS
Drosophila KDCIACKNFFDEAVSKEECP PMRKYNPTTYVLETNPEGKYA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 1210 Epidermal growth factor receptor
25 – 645 Extracellular
75 – 300 Approximate
264 – 291
275 – 275 Y -> A. Strongly reduced autophosphorylation and activation of downstream kinases; when associated with A-309.
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS GLN-98; ARG-266; LYS-521; ILE-674; GLY-962 AND PRO-988;
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