Variant position: 84 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 233 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PRDLSLISPLAQ--AVRSSSRT PSDKPVAHVVANPQAEGQLQW
Rhesus macaque PKDPSLISPLAQ--AVRSSSRT PSDKPVAHVVANPQAEGQL
Chimpanzee PRDLSLISPLAQ---AGSSSRT PSDKPVAHVVANPQAEGQL
Mouse PNGLPLISSMAQTLTLRSSSQN SSDKPVAHVVANHQVEEQL
Rat PNGLPLISSMAQTLTLRSSSQN SSDKPVAHVVANHQAEEQL
Pig PAGPLSINPLAQ--GLRSSSQT -SDKPVAHVVANVKAEGQL
Bovine PGGPSINSPLVQ--TLRSSSQA SSNKPVAHVVADINSPGQL
Rabbit PNNLHLVNPVAQMVTLRSASRA LSDKPLAHVVANPQVEGQL
Goat PAGPSFNRPLVQ--TLRSSSQA SSNKPVAHVVANISAPGQL
Sheep PAGPSFNRPLVQ--TLRSSSQA SNNKPVAHVVANISAPGQL
Cat PHGLQLINPLPQ--TLRSSSRT PSDKPVAHVVANPEAEGQL
Horse PNAFQSINPLAQ--TLRSSSRT PSDKPVAHVVANPQAEGQL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 233 Tumor necrosis factor, membrane form
77 – 233 Tumor necrosis factor, soluble form
57 – 233 Extracellular
80 – 80 O-linked (GalNAc...); in soluble form
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LEU-84;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.