UniProtKB/Swiss-Prot Q05655: Variant p.Met494Val

Protein kinase C delta type
Gene: PRKCD
Chromosomal location: 3p21.31
Variant information

Variant position:  494
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants have been found in patients and disease-association is reported in literature. However, this classification is not a definitive assessment of variant pathogenicity.
  • Polymorphism: No disease-association has been reported.
  • Unclassified: Variants have been found in patients but disease-association remains unclear.

Residue change:  From Methionine (M) to Valine (V) at position 494 (M494V, p.Met494Val).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are medium size and hydrophobic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page



Sequence information

Variant position:  494
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  676
The length of the canonical sequence.

Location on the sequence:   LKLDNVLLDRDGHIKIADFG  M CKENIFGESRASTFCGTPDY
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDY

Mouse                         LKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDY

Rat                           LKLDNVMLDKDGHIKIADFGMCKENIFGENRASTFCGTPDY

Dog                           LKLDNVMLDQDGHIKIADFGMCKENIFGEKQASTFCGTPDY

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 676 Protein kinase C delta type
Chain 330 – 676 Protein kinase C delta type catalytic subunit
Domain 349 – 603 Protein kinase
Modified residue 503 – 503 Phosphoserine
Modified residue 507 – 507 Phosphothreonine; by autocatalysis
Mutagenesis 507 – 507 T -> A. No effect on kinase activity.


Literature citations

Identification of multiple, novel, protein kinase C-related gene products.
Palmer R.H.; Ridden J.; Parker P.J.;
FEBS Lett. 356:5-8(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 432-533 (ISOFORM 1); VARIANT VAL-494;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.