Variant position: 46 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 140 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VAEAAGKTKEGVLYVGSKTK EGVVHGVATVAEKTKEQVTNV
Gorilla VAEAAGKTKEGVLYVGSKTK EGVVHGVATVAEKTKEQVTNV
Rhesus macaque VAEAAGKTKEGVLYVGSKTK EGVVHGVATVAEKTKEQVTNV
Chimpanzee VAEAAGKTKEGVLYVGSKTK EGVVHGVATVAEKTKEQVTNV
Mouse VAEAAGKTKEGVLYVGSKTK EGVVHGVTTVAEKTKEQVTNV
Rat VAEAAGKTKEGVLYVGSKTK EGVVHGVTTVAEKTKEQVTNV
Pig VAEAAGKTKEGVLYVGSKTK EGVVHGVTTVAEKTKEQVTNV
Bovine VAEAAGRTKEGVLYVGSKTK EGVVHGVTTVAEKTKEQVTNV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 140 Alpha-synuclein
42 – 56 3; approximate
20 – 67 4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)
50 – 50 Copper
41 – 54 Missing. In isoform 2-5.
35 – 35 E -> K. No effect on oligomerization.
39 – 39 Y -> F. No effect on osmotic stress-induced phosphorylation.
50 – 50 H -> A. Impairs copper-binding.
57 – 57 E -> K. Increases oligomerization.
45 – 47
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.