Variant position: 776 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 917 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NILIDFTKKGFLFRGQISET LKTRGIFETKFLSQIESDRLA
Mouse NILIDFTKKGFLFRGQISEP LKTRGIFETKFLSQIESDRLA
Rat NILIDFTKKGFLFRGQISEP LKTRGIFETKFLSQIESDRLA
Bovine NILIDFTKKGFLFRGQISEP LKTRGIFETKFLSQIESDRLA
Drosophila IIVLRLMKSGAIFAEDRRDY IGIQWKLDMVSLIEIVSDPPG
Fission yeast RILLDLYEQGALFNGQDVTK IRDPLAMDTSVLSAIEVDPFE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous.
Nishi S.; Seino S.; Bell G.I.;
Biochem. Biophys. Res. Commun. 157:937-943(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT MET-776;
A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates.
Magnani M.; Bianchi M.; Casabianca A.; Stocchi V.; Daniele A.; Altruda F.; Ferrone M.; Silengo L.;
Biochem. J. 285:193-199(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-917; VARIANT MET-776;
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