UniProtKB/Swiss-Prot P20701: Variant p.Arg214Trp

Integrin alpha-L
Gene: ITGAL
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Variant information Variant position:

214 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Arginine (R) to Tryptophan (W) at position 214 (R214W, p.Arg214Trp). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from large size and basic (R) to large size and aromatic (W) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

-3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources:

Links to websites of interest for the variant.

Variant rs1064524 [ dbSNP | Ensembl ]

Sequence information Variant position:

214 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

1170 The length of the canonical sequence.
Location on the sequence:

AAVQFSTSYKTEFDFSDYVK R KDPDALLKHVKHMLLLTNTF The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         AAVQFSTSYKTEFDFSDYVKR-KDPDALLKHVKHMLLLTNTF

Mouse                         AAVQFSTDCRTEFTFLDYVKQNKNPDVLLGSVQPMFLLTNT

Bovine                        AAVQFSTYFRTEFTFLDYIRQ-KDPDALLAGVKHMRLLTNT

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	26 – 1170	Integrin alpha-L
Topological domain	26 – 1090	Extracellular
Domain	156 – 327	VWFA
Helix	208 – 214

Literature citations
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
Larson R.S.; Corbi A.L.; Berman L.; Springer T.;
J. Cell Biol. 108:703-712(1989)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); PROTEIN SEQUENCE OF 120-132; 226-237; 282-288; 433-441; 522-531; 569-582; 591-604; 831-844 AND 957-974; DOMAIN; VARIANT TRP-214; Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS HIS-144; TRP-214; LYS-746 AND THR-791; Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
Loftus B.J.; Kim U.-J.; Sneddon V.P.; Kalush F.; Brandon R.; Fuhrmann J.; Mason T.; Crosby M.L.; Barnstead M.; Cronin L.; Mays A.D.; Cao Y.; Xu R.X.; Kang H.-L.; Mitchell S.; Eichler E.E.; Harris P.C.; Venter J.C.; Adams M.D.;
Genomics 60:295-308(1999)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2); VARIANT TRP-214;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.