Variant position: 734 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KIKVLGSGAFGTVYKGLWIP EGEKVKIPVAIKELREATSPK
Rhesus macaque KIKVLGSGAFGTVYKGLWIP EGEKVKIPVAIKELREATSPK
Mouse KIKVLGSGAFGTVYKGLWIP EGEKVKIPVAIKELREATSPK
Drosophila KGGVLGMGAFGRVYKGVWVP EGENVKIPVAIKELLKSTGAE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 1210 Epidermal growth factor receptor
669 – 1210 Cytoplasmic
712 – 979 Protein kinase
745 – 745 ATP
716 – 716 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
737 – 737 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
754 – 754 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
406 – 1210 Missing. In isoform 2.
629 – 1210 Missing. In isoform 4.
706 – 1210 Missing. In isoform 3.
745 – 745 K -> AM. Abolishes kinase activity.
734 – 736
No reference for the current variant in UniProtKB/Swiss-Prot.
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