Variant position: 790 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DNPHVCRLLGICLTSTVQLI TQLMPFGCLLDYVREHKDNIG
Rhesus macaque DNPHVCRLLGICLTSTVQLI TQLMPFGCLLDYVREHKDNIG
Mouse DNPHVCRLLGICLTSTVQLI TQLMPYGCLLDYVREHKDNIG
Drosophila EHVNLLKLLAVCMSSQMMLI TQLMPLGCLLDYVRNNRDKIG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
Yun C.H.; Mengwasser K.E.; Toms A.V.; Woo M.S.; Greulich H.; Wong K.K.; Meyerson M.; Eck M.J.;
Proc. Natl. Acad. Sci. U.S.A. 105:2070-2075(2008)
Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 695-1022 OF VARIANT MET-790; CATALYTIC ACTIVITY; CHARACTERIZATION OF VARIANT MET-790;
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
Tam I.Y.S.; Chung L.P.; Suen W.S.; Wang E.; Wong M.C.M.; Ho K.K.; Lam W.K.; Chiu S.W.; Girard L.; Minna J.D.; Gazdar A.F.; Wong M.P.;
Clin. Cancer Res. 12:1647-1653(2006)
Cited for: VARIANTS ALA-709; LYS-709; ALA-719; ASP-719; CYS-719; SER-719; SER-724; LYS-734; GLU-746 DEL; PHE-747; 747-LEU--GLU-749 DEL; PRO-748; 752-SER--ILE-759 DEL; ARG-787; MET-790; VAL-833; LEU-834; MET-858; ARG-858; GLN-861 AND GLU-873; POSSIBLE INVOLVEMENT IN LUNG CANCER;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.