Variant position: 125 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1432 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SESKCYLFHVSSMSVFPQGL KMLLENKAVKKAGVGIEGDQW
Mouse SESKCYLFHISSMSVFPQGL KMLLENKSIKKAGVGIEGDQW
Xenopus laevis SEKKCYLFHISPMAGFPKGL KRLLEDESVRKVGVGIEGDQW
Caenorhabditis elegans -------------------- ----DNDELPETEPESDSDKP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 1432 Werner syndrome ATP-dependent helicase
60 – 228 3'-5' exonuclease
2 – 277 Interaction with WRNIP1
145 – 145 Interaction with DNA
145 – 145 W -> A. Reduces exonuclease activity.
122 – 128
No reference for the current variant in UniProtKB/Swiss-Prot.
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