UniProtKB/Swiss-Prot Q8NHQ9: Variant p.Asn264Ser

ATP-dependent RNA helicase DDX55
Gene: DDX55
Feedback?

Variant information Variant position:

264 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:

LB/B The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Asparagine (N) to Serine (S) at position 264 (N264S, p.Asn264Ser). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:

Change from medium size and polar (N) to small size and polar (S) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:

1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page
Other resources:

Links to websites of interest for the variant.

Variant rs11057306 [ dbSNP | Ensembl ]

Sequence information Variant position:

264 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:

600 The length of the canonical sequence.
Location on the sequence:

NYYMVCKADEKFNQLVHFLR N HKQEKHLVFFSTCACVEYYG The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         NYYMVCKADEKFNQLVHFLRNHKQ--EKHLVFFSTCACVEYYG

Mouse                         NHYMICKADEKFNQLVHFLRSRQQ--EKHLVFFSTCACVEY

Bovine                        NHYMVCKADEKFNQLVHFLRNHKQ--EKHLVFFSTCACVEY

Chicken                       NYYMICKADEKFNQLVHFLRQHKQ--EKHLVFFSTCACVEY

Xenopus laevis                NYYMICKADEKFNKLIAFLQKRKQ--EKHLVFFSTCACVEY

Zebrafish                     NYYTMCRAEEKFNTLVAFLRQHKH--EKQLVFFSTCACVEY

Caenorhabditis elegans        NYYVECRADEKTSVCLEFIRQRTD--KKILIFFPSCNSVRY

Drosophila                    NFYRIVEPELKFVALLEFLSSPATVIGKVMVFFPTCACVEY

Slime mold                    NRYMIVPVEERLNQLVHFLLNHIDK-NKIIIYFLTCSTVDY

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 600	ATP-dependent RNA helicase DDX55
Domain	254 – 402	Helicase C-terminal
Alternative sequence	1 – 393	Missing. In isoform 2.

Literature citations
The full-ORF clone resource of the German cDNA consortium.
Bechtel S.; Rosenfelder H.; Duda A.; Schmidt C.P.; Ernst U.; Wellenreuther R.; Mehrle A.; Schuster C.; Bahr A.; Bloecker H.; Heubner D.; Hoerlein A.; Michel G.; Wedler H.; Koehrer K.; Ottenwaelder B.; Poustka A.; Wiemann S.; Schupp I.;
BMC Genomics 8:399-399(2007)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-532 (ISOFORM 1); VARIANT SER-264;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.