Variant position:  179

Type of variant:  Polymorphism

Residue change:  From Threonine (T) to Methionine (M) at position 179 (T179M, p.Thr179Met).

Physico-chemical properties:  Change from medium size and polar (T) to medium size and hydrophobic (M)

BLOSUM score:  -1

Other resources:  

• Variant rs1466684 [ dbSNP | Ensembl ]

Variant position:  179

Protein sequence length:  354

Location on the sequence:   FAKTVSIFIWFFLFFISLPN  T ILSNKEATPSSVKKCASLKG

Residue conservation: 

Human                         FAKTVSIFIWFFLFFISLPNTILSNKEATPSSVKKCASLKG

Mouse                         FAKTVSISVWSLMFFISLPNMIL-NKEATPSSVKKCASLKS

Rat                           FAKIVSISIWLLMFLISLPNMIL-NKEATASTVKKCASLKS

Sequence annotation in neighborhood:  

Discovery and mapping of ten novel G protein-coupled receptor genes.
Lee D.K.; Nguyen T.; Lynch K.R.; Cheng R.; Vanti W.B.; Arkhitko O.; Lewis T.; Evans J.F.; George S.R.; O'Dowd B.F.;
Gene 275:83-91(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; ALTERNATIVE SPLICING (ISOFORM 2); VARIANT MET-179;

Identification of a novel human ADP receptor coupled to Gi.
Communi D.; Gonzalez N.S.; Detheux M.; Brezillon S.; Lannoy V.; Parmentier M.; Boeynaems J.-M.;
J. Biol. Chem. 276:41479-41485(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); FUNCTION; VARIANT MET-179;

An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.
Wittenberger T.; Schaller H.C.; Hellebrand S.;
J. Mol. Biol. 307:799-813(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT MET-179;

Molecular cloning of FKSG77, a novel gene encoding a putative G-protein-coupled receptor.
Wang Y.-G.; Gong L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT MET-179;

Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T.; Suzuki Y.; Nishikawa T.; Otsuki T.; Sugiyama T.; Irie R.; Wakamatsu A.; Hayashi K.; Sato H.; Nagai K.; Kimura K.; Makita H.; Sekine M.; Obayashi M.; Nishi T.; Shibahara T.; Tanaka T.; Ishii S.; Yamamoto J.; Saito K.; Kawai Y.; Isono Y.; Nakamura Y.; Nagahari K.; Murakami K.; Yasuda T.; Iwayanagi T.; Wagatsuma M.; Shiratori A.; Sudo H.; Hosoiri T.; Kaku Y.; Kodaira H.; Kondo H.; Sugawara M.; Takahashi M.; Kanda K.; Yokoi T.; Furuya T.; Kikkawa E.; Omura Y.; Abe K.; Kamihara K.; Katsuta N.; Sato K.; Tanikawa M.; Yamazaki M.; Ninomiya K.; Ishibashi T.; Yamashita H.; Murakawa K.; Fujimori K.; Tanai H.; Kimata M.; Watanabe M.; Hiraoka S.; Chiba Y.; Ishida S.; Ono Y.; Takiguchi S.; Watanabe S.; Yosida M.; Hotuta T.; Kusano J.; Kanehori K.; Takahashi-Fujii A.; Hara H.; Tanase T.-O.; Nomura Y.; Togiya S.; Komai F.; Hara R.; Takeuchi K.; Arita M.; Imose N.; Musashino K.; Yuuki H.; Oshima A.; Sasaki N.; Aotsuka S.; Yoshikawa Y.; Matsunawa H.; Ichihara T.; Shiohata N.; Sano S.; Moriya S.; Momiyama H.; Satoh N.; Takami S.; Terashima Y.; Suzuki O.; Nakagawa S.; Senoh A.; Mizoguchi H.; Goto Y.; Shimizu F.; Wakebe H.; Hishigaki H.; Watanabe T.; Sugiyama A.; Takemoto M.; Kawakami B.; Yamazaki M.; Watanabe K.; Kumagai A.; Itakura S.; Fukuzumi Y.; Fujimori Y.; Komiyama M.; Tashiro H.; Tanigami A.; Fujiwara T.; Ono T.; Yamada K.; Fujii Y.; Ozaki K.; Hirao M.; Ohmori Y.; Kawabata A.; Hikiji T.; Kobatake N.; Inagaki H.; Ikema Y.; Okamoto S.; Okitani R.; Kawakami T.; Noguchi S.; Itoh T.; Shigeta K.; Senba T.; Matsumura K.; Nakajima Y.; Mizuno T.; Morinaga M.; Sasaki M.; Togashi T.; Oyama M.; Hata H.; Watanabe M.; Komatsu T.; Mizushima-Sugano J.; Satoh T.; Shirai Y.; Takahashi Y.; Nakagawa K.; Okumura K.; Nagase T.; Nomura N.; Kikuchi H.; Masuho Y.; Yamashita R.; Nakai K.; Yada T.; Nakamura Y.; Ohara O.; Isogai T.; Sugano S.;
Nat. Genet. 36:40-45(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT MET-179;

Submission
Mural R.J.; Istrail S.; Sutton G.G.; Florea L.; Halpern A.L.; Mobarry C.M.; Lippert R.; Walenz B.; Shatkay H.; Dew I.; Miller J.R.; Flanigan M.J.; Edwards N.J.; Bolanos R.; Fasulo D.; Halldorsson B.V.; Hannenhalli S.; Turner R.; Yooseph S.; Lu F.; Nusskern D.R.; Shue B.C.; Zheng X.H.; Zhong F.; Delcher A.L.; Huson D.H.; Kravitz S.A.; Mouchard L.; Reinert K.; Remington K.A.; Clark A.G.; Waterman M.S.; Eichler E.E.; Adams M.D.; Hunkapiller M.W.; Myers E.W.; Venter J.C.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]; VARIANT MET-179;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT MET-179;

Molecular cloning of a probable G protein-coupled receptor with three transmembrane domains.
Zhang W.; Wan T.; Cao X.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-354; VARIANT MET-179;