Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P21580: Variant p.Ala766Pro

Tumor necrosis factor alpha-induced protein 3
Gene: TNFAIP3
Feedback?
Variant information Variant position: help 766 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Alanine (A) to Proline (P) at position 766 (A766P, p.Ala766Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and hydrophobic (P) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 766 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 790 The length of the canonical sequence.
Location on the sequence: help GAHRGEPAPEDPPKQRCRAP A CDHFGNAKCNGYCNECFQFK The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         GAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCNECFQFK

Mouse                         VAHRGEPTPEEPPKQRCRAPACDHFGNAKCNGYCNECYQFK

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 2 – 790 Tumor necrosis factor alpha-induced protein 3
Chain 440 – 790 A20p37
Zinc finger 756 – 790 A20-type 7
Region 369 – 775 Interaction with TNIP1
Region 606 – 790 Sufficient for inhibitory activity of TNF-induced NF-kappa-B activity
Region 697 – 790 Required for lysosomal localization and for TRAF2 lysosomal degradation
Binding site 762 – 762
Binding site 767 – 767
Binding site 779 – 779
Binding site 782 – 782
Mutagenesis 779 – 779 C -> A. Impairs polyubiquitin binding, abolishes inhibition of IKK activation; when associated with A-782.
Mutagenesis 782 – 782 C -> A. Impairs polyubiquitin binding, abolishes inhibition of IKK activation; when associated with A-779.



Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS VAL-125; CYS-127 AND PRO-766;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.