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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q6NTF7: Variant p.Gly105Arg

DNA dC->dU-editing enzyme APOBEC-3H
Gene: APOBEC3H
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Variant information Variant position: help 105 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glycine (G) to Arginine (R) at position 105 (G105R, p.Gly105Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help There are at least 4 different haplotypes in the human population. The allele A3H-var/haplotype 2 encodes a more stable protein which is able to block HIV-1 replication. The displayed allele (haplotype 1) is unstable and inefficient to block HIV-1 replication. Additional information on the polymorphism described.
Variant description: help In allele A3H-Var; haplotype 2; allele presenting a higher expression and which is more effective in retrotransposons and HIV-1 restriction; increases protein stability. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 105 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 200 The length of the canonical sequence.
Location on the sequence: help CSSCAWELVDFIKAHDHLNL G IFASRLYYHWCKPQQKGLRL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         CSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQKGLRL

Rhesus macaque                CPSCAGELVDFIKAHRHLNLRIFASRLYYHWRPNYQEGLLL

Cat                           CPFCAEELVAFVKDNPHLSLRIFASRLYVHWRWKYQQGLRH

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 200 DNA dC->dU-editing enzyme APOBEC-3H
Domain 4 – 126 CMP/dCMP-type deaminase
Binding site 85 – 85
Binding site 88 – 88
Beta strand 102 – 110



Literature citations
A genome annotation-driven approach to cloning the human ORFeome.
Collins J.E.; Wright C.L.; Edwards C.A.; Davis M.P.; Grinham J.A.; Cole C.G.; Goward M.E.; Aguado B.; Mallya M.; Mokrab Y.; Huckle E.J.; Beare D.M.; Dunham I.;
Genome Biol. 5:R84.1-R84.11(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANTS ASN-15 DEL; LEU-18; ARG-105 AND ASP-178; Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.
OhAinle M.; Kerns J.A.; Li M.M.; Malik H.S.; Emerman M.;
Cell Host Microbe 4:249-259(2008)
Cited for: FUNCTION; CHARACTERIZATION OF VARIANTS ASN-15 DEL AND ARG-105;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.