Variant position: 192 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 280 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QSIEEREKLDGLYECILCAC CSTSCPSYWWNGDK---YLGPAVL
Mouse QSIEDREKLDGLYECILCAC CSTSCPSYWWNGDK---YLGP
Rat QSIEDREKLDGLYECILCAC CSTSCPSYWWNGDK---YLGP
Pig QSIEEREKLDGLYECILCAC CSTSCPSYWWNGDK---YLGP
Bovine QSIEDREKLDGLYECILCAC CSTSCPSYWWNGDK---YLGP
Chicken QSIEDRQKLDGLYECILCAC CSTSCPSYWWNGDK---YLGP
Xenopus laevis QSIEDRDKLDGLYECILCAC CSTSCPSYWWNADK---YLGP
Xenopus tropicalis QSIEDRDKLDGLYECILCAC CSTSCPSYWWNADK---YLGP
Zebrafish QSVEDRQKLDGLYECILCAC CSTSCPSYWWNADK---YLGP
Caenorhabditis elegans QSVAERDRLDGLYECILCAC CSTSCPSYWWNADK---YLGP
Drosophila QSVEDRSKLDGLYECILCAC CSTSCPSYWWNAEK---YLGP
Slime mold QSKENRHKLDGLYECILCAC CSTSCPSYWWSEGGDGGYLGP
Baker's yeast QSIEDRKKLDGLYECILCAC CSTSCPSYWWNQEQ---YLGP
Fission yeast QSRADRAKLDGLYECILCAC CSTSCPSYWWNSEE---YLGP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
29 – 280 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
176 – 206 4Fe-4S ferredoxin-type
186 – 186 Iron-sulfur 2 (4Fe-4S)
189 – 189 Iron-sulfur 2 (4Fe-4S)
192 – 192 Iron-sulfur 2 (4Fe-4S)
196 – 196 Iron-sulfur 3 (3Fe-4S)
201 – 201 Ubiquinone; shared with DHSD
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.