Variant position: 7 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 984 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human METKGY HSLPEGLDMERRWGQVSQAVE
Mouse METKGY HSLPEGLDMERRWSQVSQTLE
Rat METKGY HSLPEGLDMERRWSQVSQTLE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 984 Mineralocorticoid receptor
1 – 602 Modulating
Mechanistic aspects of mineralocorticoid receptor activation.
Hellal-Levy C.; Fagart J.; Souque A.; Rafestin-Oblin M.-E.;
Kidney Int. 57:1250-1255(2000)
Cited for: MUTAGENESIS OF ASN-770; GLN-776; ARG-817 AND THR-945;
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.
Fagart J.; Huyet J.; Pinon G.M.; Rochel M.; Mayer C.; Rafestin-Oblin M.-E.;
Nat. Struct. Mol. Biol. 12:554-555(2005)
Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 731-984 OF MUTANT LEU-810 IN COMPLEXES WITH STEROID AGONISTS; CHARACTERIZATION OF VARIANT EOHSEP LEU-810; MUTAGENESIS OF GLN-776 AND ARG-817;
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-7;
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