Variant position: 92 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1432 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLSDGDVVGFDMEWPPLYNR GKLGKVALIQLCVSESKCYLF
Mouse RLSDGDVVGFDMEWPPIYKP GKRSRVAVIQLCVSESKCYLF
Xenopus laevis SLLEEDVLGFDIEWPPVYTK GKTGKVALIQVCVSEKKCYLF
Caenorhabditis elegans TEPE---------------- ---------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 1432 Werner syndrome ATP-dependent helicase
60 – 228 3'-5' exonuclease
2 – 277 Interaction with WRNIP1
82 – 82 Magnesium 1; catalytic
82 – 82 Magnesium 2; catalytic
84 – 84 Magnesium 1; catalytic
84 – 84 E -> A. Abolishes exonuclease activity.
88 – 88 L -> A. No effect on exonuclease activity.
No reference for the current variant in UniProtKB/Swiss-Prot.
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