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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P21912: Variant p.His132Pro

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Gene: SDHB
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Variant information Variant position: help 132 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Histidine (H) to Proline (P) at position 132 (H132P, p.His132Pro). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (H) to medium size and hydrophobic (P) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In PPGL4. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 132 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 280 The length of the canonical sequence.
Location on the sequence: help ACTRRIDTNLNKVSKIYPLP H MYVIKDLVPDLSNFYAQYKS The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ACTRRI-DTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKS

Mouse                         ACTRRI-DTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYK

Rat                           ACTRRI-DTDLGKVSKIYPLPHMYVIKDLVPDLSNFYAQYK

Pig                           ACTRRI-DTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYK

Bovine                        ACTRRI-DTNLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYK

Chicken                       ACTKKI-DPDLSKTTKIYPLPHMYVVKDLVPDLSNFYAQYK

Xenopus laevis                ACTVRI-DTNLSKVSKIYPLPHMYVVKDLVPDLSNFYAQYK

Xenopus tropicalis            ACTVRI-DTNLSKVSKIYPLPHMYVVKDLVPDLSNFYAQYK

Zebrafish                     ACLNKI-DTNTSKVTKIYPLPHMYVVKDLVPDMSNFYAQYK

Caenorhabditis elegans        ACICKI-DSDTSKSTKIYPLPHMFVVKDLVPDMNLFYAQYA

Drosophila                    ACISKI-DINTSKSLKVYPLPHMYVVRDLVPDMNNFYEQYR

Slime mold                    ACTKKITDCLSGDTVKVYPLPHMHVVRDLIPDLSHFYTQHK

Baker's yeast                 ACICKI-DQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYK

Fission yeast                 ACICNI-KKD-NKPTKIYPLPHCFIVKDLVPDLTYFYKQYK

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 29 – 280 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Domain 40 – 133 2Fe-2S ferredoxin-type
Binding site 113 – 113
Beta strand 130 – 132



Literature citations
A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas.
Maier-Woelfle M.; Braendle M.; Komminoth P.; Saremaslani P.; Schmid S.; Locher T.; Heitz P.U.; Krull I.; Galeazzi R.L.; Schmid C.; Perren A.;
J. Clin. Endocrinol. Metab. 89:362-367(2004)
Cited for: VARIANT PPGL4 PRO-132;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.