Variant position: 132 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 280 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ACTRRI-DTNLNKVSKIYPLP HMYVIKDLVPDLSNFYAQYKS
Mouse ACTRRI-DTDLSKVSKIYPLP HMYVIKDLVPDLSNFYAQYK
Rat ACTRRI-DTDLGKVSKIYPLP HMYVIKDLVPDLSNFYAQYK
Pig ACTRRI-DTNLDKVSKIYPLP HMYVIKDLVPDLSNFYAQYK
Bovine ACTRRI-DTNLSKVSKIYPLP HMYVIKDLVPDLSNFYAQYK
Chicken ACTKKI-DPDLSKTTKIYPLP HMYVVKDLVPDLSNFYAQYK
Xenopus laevis ACTVRI-DTNLSKVSKIYPLP HMYVVKDLVPDLSNFYAQYK
Xenopus tropicalis ACTVRI-DTNLSKVSKIYPLP HMYVVKDLVPDLSNFYAQYK
Zebrafish ACLNKI-DTNTSKVTKIYPLP HMYVVKDLVPDMSNFYAQYK
Caenorhabditis elegans ACICKI-DSDTSKSTKIYPLP HMFVVKDLVPDMNLFYAQYA
Drosophila ACISKI-DINTSKSLKVYPLP HMYVVRDLVPDMNNFYEQYR
Slime mold ACTKKITDCLSGDTVKVYPLP HMHVVRDLIPDLSHFYTQHK
Baker's yeast ACICKI-DQNESKQLKIYPLP HMFIVKDLVPDLTNFYQQYK
Fission yeast ACICNI-KKD-NKPTKIYPLP HCFIVKDLVPDLTYFYKQYK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
29 – 280 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
40 – 133 2Fe-2S ferredoxin-type
113 – 113 Iron-sulfur 1 (2Fe-2S)
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.