Variant position: 1034 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DEYLIPQQGFFSSPSTSRTP LLSSLSATSNNSTVACIDRNG
Rhesus macaque DEYLIPQQGFFSSPSTSRTP LLSSLSATSNNSTVACIDRNG
Mouse DEYLIPQQGFFNSPSTSRTP LLSSLSATSNNSTVACINRNG
Drosophila DDYLQPKAAPGPSHRTDCTD EMPKLNRYCKDPS----NKNS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 1210 Epidermal growth factor receptor
669 – 1210 Cytoplasmic
1016 – 1016 Important for interaction with PIK3C2B
1016 – 1016 Phosphotyrosine; by autocatalysis
1026 – 1026 Phosphoserine
1039 – 1039 Phosphoserine
1041 – 1041 Phosphothreonine
1042 – 1042 Phosphoserine
406 – 1210 Missing. In isoform 2.
629 – 1210 Missing. In isoform 4.
706 – 1210 Missing. In isoform 3.
1016 – 1016 Y -> F. 50% decrease in interaction with PIK3C2B. 65% decrease in interaction with PIK3C2B; when associated with F-1197. Abolishes interaction with PIK3C2B; when associated with F-1197 and F-1092.
No reference for the current variant in UniProtKB/Swiss-Prot.
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