Variant position: 340 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1360 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PSATKQATSISSETKNTLRA FSAPQNSESQAHVSGGGDDSS
Mouse GSA-KRATPILSETKSTLSA FSAPQNSESQTHVSGGGNDSS
Drosophila ESTIQLAEGATFQEKLKNLQ SNAKQDASYDDIVTNTSNLD-
Slime mold DD--DDDEQDDDEDDDDDDD DKKSKSTTTTAVKKKGNAFGK
Baker's yeast DNSKKKSRPNQAPSRSYNPS HSQPSAT------SKSSKFNK
Fission yeast GSQIASPSPSVSGSASPTKS NKNGVLNREEKRRQRMEAFKK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1360 DNA mismatch repair protein Msh6
Sequence analysis of the mismatch repair gene hMSH6 in the germline of patients with familial and sporadic colorectal cancer.
Plaschke J.; Kruppa C.; Tischler R.; Bocker T.; Pistorius S.; Dralle H.; Rueschoff J.; Saeger H.D.; Fishel R.; Schackert H.K.;
Int. J. Cancer 85:606-613(2000)
Cited for: VARIANT CRC SER-340; VARIANT GLU-39;
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