UniProtKB/Swiss-Prot P04637 : Variant p.Pro8Ser
Cellular tumor antigen p53
Gene: TP53
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Variant information
Variant position:
8
The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant:
US
The variants are classified into three categories: LP/P, LB/B and US.LP/P: likely pathogenic or pathogenic. LB/B: likely benign or benign. US: uncertain significance
Residue change:
From Proline (P) to Serine (S) at position 8 (P8S, p.Pro8Ser).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties:
Change from medium size and hydrophobic (P) to small size and polar (S)
The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score:
-1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another: Lowest score: -4 (low probability of substitution).Highest score: 11 (high probability of substitution). More information can be found on the following page
Variant description:
In a sporadic cancer; somatic mutation.
Any additional useful information about the variant.
Sequence information
Variant position:
8
The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length:
393
The length of the canonical sequence.
Location on the sequence:
MEEPQSD
P SVEPPLSQETFSDLWKLLPE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation:
The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEEPQSDP SVEPPLSQETFSDLWKLLPE
MEESQSEL NIDPPLSQETFSELWNLLPE
Rhesus macaque MEEPQSDP SIEPPLSQETFSDLWKLLPE
Mouse MEESQSDI SLELPLSQETFSGLWKLLPP
Rat MEDSQSDM SIELPLSQETFSCLWKLLPP
Pig MEESQSEL GVEPPLSQETFSDLWKLLPE
Bovine MEESQAEL NVEPPLSQETFSDLWNLLPE
Rabbit MEESQSDL SLEPPLSQETFSDLWKLLPE
Sheep MEESQAEL GVEPPLSQETFSDLWNLLPE
Cat MQEPPLEL TIEPPLSQETFSELWNLLPE
Chicken -MAEEMEP LLEP---TEVFMDLWSMLPY
Xenopus laevis -MEPSSET GMDPPLSQETFEDLWSLLPD
Zebrafish MAQNDSQE ----------FAELWE----
Sequence annotation in neighborhood:
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
Region
1 – 320
Interaction with CCAR2
Region
1 – 83
Interaction with HRMT1L2
Region
1 – 44
Transcription activation (acidic)
Modified residue
9 – 9
Phosphoserine; by HIPK4
Modified residue
15 – 15
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Modified residue
18 – 18
Phosphothreonine; by CK1, VRK1 and VRK2
Modified residue
20 – 20
Phosphoserine; by CHEK2, CK1 and PLK3
Cross
24 – 24
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Alternative sequence
1 – 132
Missing. In isoform 7, isoform 8 and isoform 9.
Alternative sequence
1 – 39
Missing. In isoform 4, isoform 5 and isoform 6.
Mutagenesis
15 – 15
S -> A. Loss of interaction with PPP2R5C, PPP2CA AND PPP2R1A.
Mutagenesis
18 – 18
T -> A. No effect on interaction with MDM2 and increase in protein levels after DNA damage.
Mutagenesis
20 – 20
S -> A. Abolishes phosphorylation site. Abolishes increase in protein levels after DNA damage.
Mutagenesis
20 – 20
S -> D. Constitutively increased TP53 protein levels.
Mutagenesis
24 – 24
K -> R. Abolishes ubiquitination by MUL1.
Turn
8 – 10
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.