Variant position: 63 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LMLSPDDIEQWFTEDPGPDE APRMPEAAPPVAPAPAAPTPA
Rhesus macaque LMLSPDDLAQWLTEDPGPDE APRMSEAAPPMAPTPAAPTPA
Mouse LLLP-QDVEEFF-EGP--SE ALRVSGAPAAQDPVTETPGPV
Rat LFLP-QDVAELL-EGP--EE ALQVS-APAAQEPGTEAPAPV
Pig LLLS--PVTNWLDENP--DD ASRVPAPPAA-----TAPAPA
Bovine LLPY-TDVATWLDECP--NE APQMPEPSAP-----AAPPPA
Rabbit L-LSAEDVANWLNEDP--EE GLRVPAAPAPEAPAPAAPALA
Sheep LLPYSEDVVTWLDECP--NE APQMPEP----------PAQA
Cat LPLS-EDVANWLDEAP--DD ASGMSAVPAP-----AAPAPA
Dog LLLP-ESVVNWLDEDS--DD APRMP----------ATSAPT
Chicken LPLP-EDHSNWQELSPLEPS DPPPPPPPPPLPLAAAAPPPL
Xenopus laevis --PLQTVTCRL-------DN LSEFPDYPLAADMTVLQEGLM
Zebrafish --PPGGGSC-W-------DI INDEEYLPGSFDPNFFENVLE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
1 – 320 Interaction with CCAR2
1 – 83 Interaction with HRMT1L2
46 – 46 Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG
55 – 55 Phosphothreonine; by TAF1 and GRK5
1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.
46 – 46 S -> A. Abolishes phosphorylation by DYRK2 and HIPK2 and acetylation of K-382 by CREBBP.
46 – 46 Missing. Alters interaction with WWOX.
55 – 55 T -> A. Blocks phosphorylation by TAF1.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.