Variant position: 73 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WFTEDPGPDEAPRMPEAAPP VAPAPAAPTPAAPAPAPSWPL
Rhesus macaque WLTEDPGPDEAPRMSEAAPP MAPTPAAPTPAAPAPAPSWPL
Mouse FF-EGP--SEALRVSGAPAA QDPVTETPGPVAPAPATPWPL
Rat LL-EGP--EEALQVS-APAA QEPGTEAPAPVAPASATPWPL
Pig WLDENP--DDASRVPAPPAA -----TAPAPAAPAPATSWPL
Bovine WLDECP--NEAPQMPEPSAP -----AAPPPATPAPATSWPL
Rabbit WLNEDP--EEGLRVPAAPAP EAPAPAAPALAAPAPATSWPL
Sheep WLDECP--NEAPQMPEP--- -------PAQAALAPATSWPL
Cat WLDEAP--DDASGMSAVPAP -----AAPAPATPAPAISWPL
Dog WLDEDS--DDAPRMP----- -----ATSAPTAPGPAPSWPL
Chicken WQELSPLEPSDPPPPPPPPP LPLAAAAPPPLNPPTPPRAAP
Xenopus laevis L-------DNLSEFPDYPLA ADMTVLQEGLMGNAVPTV--T
Zebrafish W-------DIINDEEYLPGS FDPNFFENVLEEQPQPSTLPP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
1 – 83 Interaction with HRMT1L2
66 – 110 Interaction with WWOX
55 – 55 Phosphothreonine; by TAF1 and GRK5
1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.
55 – 55 T -> A. Blocks phosphorylation by TAF1.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.