Variant position: 296 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ACPGRDRRTEEENLRKKGEP H--HELPPGSTKRALPNNTS-SSP
Rhesus macaque ACPGRDRRTEEENFRKKGEP C--HQLPPGSTKRALPNNTS-
Mouse ACPGRDRRTEEENFRKKEVL C--PELPPGSAKRALPTCTS-
Rat ACPGRDRRTEEENFRKKEEH C--PELPPGSAKRALPTSTS-
Pig ACPGRDRRTEEENFLKKGQS C--PEPPPGSTKRALPTSTS-
Bovine ACPGRDRRTEEENLRKKGQS C--PEPPPRSTKRALPTNTS-
Rabbit ACPGRDRRTEEENFRKKGEP C--PELPPGSSKRALPTTTTD
Sheep ACPGRDRRTEEENFRKKGQS C--PEPPPGSTKRALPSSTS-
Cat ACPGRDRRTEEENFRKKGEP C--PEPPPGSTKRALPPSTS-
Dog ACPGRDRRTEEENFHKKGEP C--PEPPPGSTKRALPPSTS-
Chicken ACPGRDRKIEEENFRKRGGA G-------GVAKRAMSPPTE-
Xenopus laevis ACPGRDRRTEEDNYTKKRGL K-----PSGKRELAHPPSSE-
Zebrafish ACPGRDRKTEESNFKKDQET KTMAKTTTGTKRSLVKESSS-
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
100 – 370 Interaction with HIPK1
100 – 300 Required for interaction with ZNF385A
284 – 284 Phosphothreonine; by AURKB
305 – 305 N6-acetyllysine
315 – 315 Phosphoserine; by AURKA, CDK1 and CDK2
291 – 291 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
292 – 292 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
284 – 284 T -> E. Inhibits strongly its transcriptional activity.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.